Targeting Mitochondrial Oxidative Phosphorylation Eradicates Acute Myeloid Leukemic Stem Cells
Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by multiple cytogenetic and molecular abnormalities, with a very poor prognosis.Current treatments for AML often fail to eliminate leukemic stem cells (LSCs), which perpetuate the disease.LSCs exhibit a unique metabolic profile, especially dependent on oxidative ph